Kamagra oral jelly is a medication used for the management of erectile dysfunction (ED). It contains the citrate salt of sildenafil as the main active ingredient. In 2005, it was estimated that worldwide, a staggering 150 million males suffer from ED, with an expectation that this number would double to 300 million by 2020 . Since its discovery and introduction as a treatment for erectile dysfunction, sildenafil citrate is being used rampantly.
Kamagra oral jelly is available as a 100mg oral sachet. It is marketed by Ajanta Pharmaceutical Company and has been available to sufferers of ED for a long time. It is more preferred by users than the pill form, due to the fact that the jelly can be taken without water and is immediately absorbed into the blood circulation from the oral mucosa itself. However, it must be kept in mind that like all drugs, Kamagra oral jelly is also a chemical substance associated with side effects. Therefore, its usage is not free from side effects, and some precautions are to be taken.
About Ajanta Pharma
Ajanta Pharmaceutical is a drug manufacturing and marketing giant with a strong global presence. Despite its main headquarter being in India, it has an extensive presence in more than 30 countries including USA, Philippines, Southeast Asia and Africa . Over the years, Ajanta has established itself as a strong and reliable supplier of generic medications. It is also actively involved in research and development of new drugs and substances and has set up various R&D facilities throughout India. According to Ajanta Pharma website, it has USA-FDA approval, is GMP-certified and has been the recipient of numerous awards for quality and excellence over the years. With its rapid progress, over the last few years, Ajanta Pharmaceuticals has also been on the list of Forbes Asia top 10 companies as well as one of the top 10 pharmaceutical companies in Franco Africa . This industry began selling medications in the USA markets from 2013 and has already been approved by the FDA for at least 16 drugs, according to their website .
Scientific Studies on Sildenafil
US FDA approved Sildenafil in 1998. Since then and even before that, it has been the subject of many studies, clinical trials, and research to establish its mechanism of action, efficacy and safety profile.
Globally, ED is prevalent everywhere and is a major contributor of sexual disorders. Its prevalence increases with age and poses significant physical and psychological morbidity in men. In 1998 Goldstein et al.  published a Sildenafil Group study named ‘Oral sildenafil in the treatment of erectile dysfunction. New England Journal of Medicine’, which proved that Sildenafil improves erectile dysfunction in a dose-related manner. There was a significant improvement in the sexual performance of those patients taking sildenafil compared to those taking a placebo. Following the publication of this study, there was no going back for sildenafil and treatment of ED. Pfizer was the first pharmaceutical company to market it under the trade name of Viagra.
Subsequently, USA-FDA approved sildenafil for the treatment of ED. Following this, there were numerous studies, clinical trials, randomized control studies and reviews to establish the potency, long-term efficacy and side effects of sildenafil. Almost all the results are in favor of Sildenafil. Konstantinos published a research ‘Sildenafil in the treatment of erectile dysfunction: an overview of the clinical evidence’ in the Journal of Interventional Aging about the long-term efficacy of Sildenafil . The long term use of Sildenafil [more than 3 years] was studied and side effects, potency, and satisfaction was recorded. According to this study, “Satisfaction and improvement in the ability to engage in sexual activity reported in 96% and 99% of patients respectively” after 3 years only around 32 % of patients discontinued the use of sildenafil. Out of this 32 %, more than 25 % discontinued due to reasons unrelated to the medication itself. There was a concern of developing tachyphylaxis to long term use of Sildenafil. However, this is still a speculation, and no clinical trials and data support this claim. It is also to be noted that Sildenafil is not a cure, rather a treatment of ED. That is, on discontinuation of the drug, symptoms will eventually return. This is because ED itself is mostly a disease associated with the normal process of aging and hence impossible to reverse. It can, however, be managed with sildenafil to minimize its impact on quality of life.
Description and Mechanism of Action of Sildenafil
Sildenafil is an enzyme inhibitor. Usually, in blood vessels two substances namely cGMP and nitric oxide cause vasodilatation. CGMP is broken down by the enzyme phosphodiesterase type 5 (PDE 5), ending its vasodilatation action. Sildenafil, by blocking the action of PDE 5 causes cGMP to stay longer in the blood and prolong the erection.
Effects of Sildenafil
Sildenafil is expected to cause vasodilatation of blood vessels in the erectile tissues of the penis, namely, the corpus cavernosum. In males, who have been sexually aroused, this leads to an initiation and prolongation of erection by causing increased blood flow to the penis. This vasodilatation property is also used to treat pulmonary hypertension, where it effectively reduces the pressure in the lungs by causing vasodilatation.
Recommended Doses and Duration of Therapy
Physicians recommend an initial dose of 50 mg of Sildenafil to be taken around 1 hour before sexual intercourse if maximum efficacy is desired. However, this dose can be increased to 100 mg. Typically, only half sachet (50 mg) of the Kamagra oral jelly is required by elderly users above 65 years old.
Side Effects and Warnings
Side effects of Sildenafil have been documented various times. However, fortunately, repeated studies have shown that these were seldom serious enough to warrant discontinuation. However, a dose reduction has been recommended in few cases. Also, most effects gradually decrease with time.
A headache is the most frequently reported secondary to vasodilatation in brain blood vessels. Others are flushing of the face, dizziness, stomach upset and abnormal vision. People with co-morbidities like hypertension and diabetes are also warned to take the drug with precautions.
A dose reduction to 25 mg is also recommended in the elderly population of above 65 years of age. Furthermore, people with renal or hepatic diseases are also advised to take a reduced dose. Those with an anatomical abnormality of the penis like priapism are also warned to consult a physician. Lastly, Sildenafil is a prescription drug and should be bought only after being advised by doctors. Of the most serious adverse effects of sildenafil, chest pain, priapism, and loss of vision are most feared.
Sildenafil, the active ingredient of Kamagra Oral Jelly, is known to interact with a few drugs. Of utmost importance are the nitrates, including nitroglycerin and amyl nitrites. Concomitant use of both drugs can cause dangerous hypotension as both drugs act as vasodilators.
A manufacturer can claim its product to be excellent, but its efficacy is proved only if it has satisfied its users. In the case of Kamagra oral jelly, some of the following feedback were found.
One user, Beastmaster  has claimed that it is powerful stuff. He has tried different brands of Viagra but “this is among the best that I have had’’ he said. He also mentions that the onset of action was very quick and he was satisfied. However, the shipping took a long time. On the other hand, Douglas mentions that it is a quality product. It is 100% potent and “works like any other branded product….and above all no side effect’’. We also have J from Noordjwik  who claims that he uses Kamagra only a few times, but has been satisfied by it as it acts fairly quickly. He, however, suffers from a headache because of it.
From the above reviews, it appears that the level of user’s satisfaction from Kamagra is high. The product delivers what it promised. As most customers are happy with the product, the recommendation to buy Kamagra oral jelly is stronger. With a myriad of generic drugs available for Sildenafil, positive reviews for Kamagra only cements its position as one of the best generic versions available of the drug.
Kamagra Oral Jelly Price, Available Forms and Dosage
A number of online pharmacies sell Kamagra in both pills and jelly form. One sachet costs approximate $1.87 with the jelly form having similar prices. In many online pharmacies, it is also available in bulk of 100 pills at $204.27. Though the prices are quite affordable in comparison to the branded version of Sildenafil like Viagra, there is still shipping fee to be paid.
This can range from $25 to $29.93, depending on the site ordered and location. Alldaychemist.com charges a flat rate of $25 for delivery products to any listed destinations including USA, UK and Australia. Another site, medicationslistaz.com  provides standard airmail service free of cost and charge $29.93 for shipping products to the destination using Trackable service.
Hence, depending on options of free coupon codes, discounts and free shipping on certain products, an excellent value for money can be expected from reliable online pharmacies. The recommended dose of Kamagra oral jelly is 50 mg to 100 mg once daily.
Conclusion and Rating
Kamagra Oral jelly is manufactured and marketed by Ajanta Pharmaceutical for the treatment of ED in men. The main active ingredient of Kamagra oral jelly is sildenafil, a substance being used for the treatment of ED since 1998. Various clinical studies, trials, reviews, and papers have proven the safety and efficacy of Sildenafil beyond doubt, despite the fact that Sildenafil is associated with certain side effects. Consumer reviews for Kamagra Oral Jelly are also mostly positive and encouraging. Users are satisfied with its rapid onset due to gelatinous form, potency, and minimal side effects. Kamagra is also easily available both locally and internationally along with online pharmacies. Ajanta Pharmaceutical, being a highly reputable company, has its branches in numerous countries including the USA. It also has FDA approval for Kamagra. In a world rift with inflation and high prices, Kamagra Oral Jelly is a cheap alternative for those requiring it for a long time. However, Sildenafil is a prescription drug, and the opinion of a doctor should be taken before opting for it.
I would give Kamagra a rating of 4 out of 5 stars and would certainly recommend it as a cost effective alternative to Viagra.
Kamagra Oral Jelly Wiki Facts
- Brand: Kamagra Oral Jelly
- Active Ingredient: Sildenafil
- Treatment: Erectile Dysfunction
- Manufacturer: Ajanta
- Country of Manufacture: India
- Availability: USA, New Zealand, UK, India, Australia, EU
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- Ajanta Pharma Limited: Ajanta Pharmaceuticals Ltd.; [cited 2016 26th Noc]. Available from: http://www.ajantapharma.com/overview.html.
- Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA. Oral sildenafil in the treatment of erectile dysfunction. New England Journal of Medicine. 1998 May 14;338(20):1397-404. Available from: http://www.nejm.org/doi/full/10.1056/NEJM199805143382001?ck=nck&
- Hatzimouratidis K. Sildenafil in the treatment of erectile dysfunction: an overview of the clinical evidence. Clin Interv Aging. 2006 Dec; 1(4): 403-414. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699643/
- AllDayChemist. Week Pack Kamagra Oral Jelly – 100 mg: AllDayChemist.com; [cited 2016 25th Nov]. Available from: https://www.alldaychemist.com/week-pack-kamagra-oral-jelly-100-mg.html.
- Erectiemiddelenshop.nl. Kamagra Oral Jelly: Erectile Resource Shop; 2016 [cited 2016 25th Nov]. Available from: https://www.erectiemiddelenshop.nl/kamagra-oral-jelly.html#product_tabs_product_additional_data.
- Medicationslistaz.com. Shopping cart of Kamagra Oral Jelly: Australia Chemist; [updated 30th Oct 2016; cited 2016 25th Nov]. Available from: http://medicationslistaz.com/cart.php?add=70076.
- Medline Plus. Sildenafil USA: American Society of Health-System Pharmacists; [updated 15th July 2015; cited 2016 25th Nov]. Available from: https://medlineplus.gov/druginfo/meds/a699015.html.