Kamagra Chewable Tablets, which contain sildenafil citrate, is a drug used in the treatment of erectile dysfunction (impotence). The product should be taken one hour before sexual intercourse. It is advisable to take it on an empty stomach and drink a large glass of water to avoid delaying in action. The duration of the action of the drug is 4 hours. However, it won’t work without sexual stimulation .There are some contraindications as heart diseases, people taking nitrate drugs, women, and children. It is advisable to take the maximum recommended dose once per day . The available forms of Kamagra are tablet, chewable tablet, effervescent tablet, and oral jelly. Despite, the significant action of Kamagra chewable tablets, there are some side effects as a headache, dyspepsia, abnormal vision, diarrhea, dizziness, and back pain .
About Ajanta Pharma
Ajanta Pharma is a specialty pharmaceutical company engaged in the development, manufacture and marketing of quality finished dosages. It is a company located in India which specializes in the manufacturing of generic medications. Based on the information on the company’s site, it is already a US FDA-approved institution . Aside from being US FDA-approved, it is also compliant with the standards set by the World Health Organization’s cGMP guidelines . Ajanta Pharma currently has 5 “state-of-the-art” facilities all over India and is stationed in Mumbai . The product range of this company is vast, as it has made generic versions of almost all of the common brand-name meds in the market. Also, it has been receiving recognition for its efforts in different fields. It is listed in “Fastest Growing Company in India” and Ranked 21st by Outlook Business Magazine (2016). Also, Ajanta Pharma is awarded Gold Trophy for Quality Excellence from Indian Drug Manufacturer’s Association (2011). Recently, it has joined the USA markets with its portfolio that contains a collection of technology products to have the challenging advantage in the market place. It is expecting the US market to be its key growth driver in the coming years .
Scientific Studies on Sildenafil
In the study “Sildenafil taken at bedtime significantly increases nocturnal erections: results of a placebo-controlled study” by Francesco Montors (2000). The aim was to value the effect of Sildenafil on nocturnal erections compared to a placebo administered at bedtime. This was done by a double-blind, crossover, placebo-controlled study that tested the effects of Sildenafil and placebo on thirty patients with erectile dysfunction (22 patients with vasculogenic etiology; 8 patients with psychogenic etiology). These patients were admitted to a polysomnographic recording of nocturnal erections, by using a RigiScan device during 3 successive nights. The first night was for adaptation. There was a study of the patients after intake of Sildenafil or a placebo at bedtime in the 2 following nights. The results showed that there was an improvement in nocturnal erectile activity in twenty-three patients after the intake of Sildenafil and 5 patients developed similar nocturnal erections with both Sildenafil and placebo. But 2 patients had a significant improvement in nocturnal erectile activity after taking the placebo only. In brief, there was an improvement in mean rigidity and tumescence activity values at the tip and base of the penis after intake of Sildenafil compared to placebo .
Another study named “a placebo-controlled study of Sildenafil effects on cognition in schizophrenia” by Donald C. Goff (2009) had the aim to evaluate the effects of Sildenafil on seventeen adults suffering from schizophrenia and taking a regular dose of anti-schizophrenia drug (antipsychotic drug). This was done by giving the patients a single oral dose of sildenafil (100mg) randomly. They maintained 48 hours between administrations. After one hour from intake of each drug, psychiatric symptom ratings, and a cognitive battery were done. In addition, after 48 hours there was an examination of memory consolidation before the following administration of the drug. The result was that fifteen subjects accomplished all three treatment conditions. But one patient had irritability and required to enter the hospital two days from taking Sildenafil 100 mg. Despite the ability of Sildenafil in cognitive enhancement performance in animal models, it didn’t significantly affect psychiatric symptoms or cognitive performance in schizophrenia patients compared to placebo. In brief, the mechanism of treating memory defects in schizophrenia with Sildenafil was not successful .
Also, there is a study named “The PDE5 Inhibitor Sildenafil Increases Circulating Endothelial Progenitor Cells and CXCR4 Expression” by Carlo Foresta MD (2008). Endothelial progenitor cells (EPC) are an important subclass of progenitor cells that are derived from mononuclear cells. They contribute to vascular repair by migrating from bone marrow to peripheral circulation. Also, CXC-motif chemokine receptor 4 (CXCR4) receptor has a significant role in this process. The aim of the study is to value the effects of Sildenafil intake which inhibitsphosphodiesterase type 5 in twenty healthy young men. This is done by assessment of CXCR4 expression in endothelial progenitor cells before in vivo intake of sildenafil (100mg) by using colony counter (colony-forming unit) and technique of flow cytometry and repeating this process after 4 hours by the same procedures. There was a marked increase in endothelial progenitor cells level, expression of CXCR4 on these cells. Also the ability to develop colonies in vitro increased. From this information, we think that there is an interference of PDE5 in peripheral homing of endothelial progenitor cells and bone marrow release of them .
Description and Mechanism of Action of Sildenafil
Kamagra Chewable Tablets contain Sildenafil which has a significant role in the treatment of erectile dysfunction. It causes erection by acting on the erectile tissue of the penis and increasing blood flow. During sexual stimulation, nitric oxide has a critical function in the mechanism of erection by activating the enzyme guanylate cyclase which causes an increase in the number of cyclic guanosine monophosphate (cGMP) which causes erection by relaxing the blood vessels in the penis and allowing blood to fill the spongy erectile tissues. Another cause of erectile dysfunction is the action of enzyme phosphodiesterase type 5 (PDE5) which prevents blood flow to the penis by breaking down cGMP. The mechanism by which Kamagra 100mg tablets treat erectile dysfunction is that they inhibit the action of phosphodiesterase type 5 and allow sexual stimulation to increase cyclic guanosine monophosphate which maintains erection .
Kamagra Chewable Tablets Effects
Since Kamagra 100mg tablets contain Sildenafil, it is expected to treat erectile dysfunction (impotence) in men (inability to have a hard erect penis for normal sexual activity). Also, Kamagra 100mg tablets cause erection by relaxing the blood vessels in the penis and increasing blood flow which is the normal response to sexual stimulation. Patients can expect normal erection and enjoy their sex lives with as much ease as they used to do it earlier .
Recommended Doses and Duration of Therapy
The recommended dose of Kamagra Soft Chewable tablets in adults is 100 mg. It should be taken one hour before doing any sexual activity. It is advisable to take the maximum recommended dose once per day. If you take Sildenafil Soft Tablets with food, there will be a delay in the start of medical effect compared to the administration in the fasted state. It is necessary to have the second dose after 24 hours from the previous one. If you want to take the drug, you should have a prescription. .
Side Effects and Warnings
Kamagra Chewable Tablets have shown progress in the treatment of erectile dysfunction. However, there are serious side effects like flushing of the face, headache, and upset of stomach. Others as dizziness, skin rash, diarrhea, urinary tract infection, back pain and nasal congestion are less likely to occur. They are mild and don’t last for a longer time just a few hours. They usually occur when the patients take higher doses. Also, there are temporary manifestations in vision as blurred vision, and the eye will be more sensitive to light. Also, patients will have trouble in telling the difference between blue and green objects. .
Despite the significant action of Kamagra Soft tablets in the treatment of erectile dysfunction, there are drugs which can interact with it and increase the risk of serious adverse effects. These drugs are other impotence drugs like Vardenafil, Antibiotics as Erythromycin and Antidepressants. Also, Antifungal drugs such as Itraconazole, Blood Pressure medications like Diltiazem, Quinidine, or Hepatitis C drugs like Boceprevir or Telaprevir can interact with them .
Kamagra Chewable Tablets have several online reviews that talk about their effectiveness and a low price when compared to other brand name drugs like Cialis and Viagra. There were a few reviews for Kamagra chewable tablets on the web indicating that the patients who tried the product were satisfied with the result. The only issue reported was a discoloration of the tongue, so they recommended drinking water.
Based on the reviews, the patients seemed satisfied with the results brought about by Kamagra chewable tablets. Online reviews increase confidence in a product and service, and more than two-thirds of individuals check what others say about the product in the online reviews.
Price, Available Forms, and Dosage
Single Kamagra Chewable Tablet costs $1.94. Reliablecanadapharmacy.com charges a flat shipping charge of $9.99 to any country listed on the site including USA, UK, and Australia.
Another online store, genericpharmashop.com charges a fixed fee of $25 for any listed country including USA, Australia, and the UK, though it has a shipping charge calculator. This store also delivers drugs for free for a certain amount of purchase in a single order.
The available dosage form of Kamagra is Tablet, Chewable tablet, effervescent tablet, and oral jelly. The recommended dose is 100 mg taken approximately one hour before sexual activity.
Conclusion and Rating
There is no question regarding the effectiveness of Kamagra chewable tablets, as they are still the most effective treatment existing in the market. But there were some concerns regarding their adverse effects like a headache, urinary tract infection, abnormal vision, diarrhea, dizziness, respiratory tract infection, and back pain. The reliability of Sildenafil was also proven by the research not only in erectile dysfunction, but also in improving functional capacity. There were a few reviews stating that Kamagra tablets are effective in treatment erectile dysfunction, but the tongue discoloration was noticed, so the patients recommended drinking some water while chewing. It is effective, as it contains Sildenafil which was meant for treating erectile dysfunction. Kamagra tablets are also manufactured by Ajanta Pharma, which is an FDA-approved institution. But as for my rating, I can rate it with 4 points out of 5; I recommend using the product, but under the supervision of a doctor alone.
Kamagra Chewable Tablets Wiki Facts
- Brand: Kamagra Chewable Tablets
- Active Ingredient: Sildenafil
- Treatment: Erectile Dysfunction
- Manufacturer: Ajanta
- Country of Manufacture: India
- Availability: EU, USA, UK, New Zealand, +
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9. Description and Mechanism of Action of ‘Sildenafil. Retrieved from: https://www.inhousepharmacy.vu/p-224-kamagra-100mg-tablets.aspx
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