Kamagra Oral Jelly is a product branded by Ajanta Pharmacy which contains Sildenafil. Generally, Sildenafil is prescribed by physicians to cure E.D (Erectile Disorder) in men. Since several years, Sildenafil is considered to play one of the most effective roles for patients with erectile dysfunction. So, Ajanta Pharma introduced several forms of Sildenafil medication including Kamagra Oral Jelly.
Kamagra Jelly is sold as a gel packed in small packets having different kinds of fruit flavors.
Currently, it is available in pineapple, strawberry, caramel, cherry flavors. The recommended dose for a healthy man is 100 mg which can vary with the age and intensity of his erectile disorder.
The mechanism for Sildenafil is not so complicated; it works by inhibiting the function of phosphodiesterase type-5 resulting relaxation of blood vessels inside Corpus Cavernosum of the penis. As it doesn’t have any effect on systemic blood circulation, blood pressure and heart rate of a patient seem to be absolutely fine.
Patients are advised to take one piece of Kamagra Oral jelly before an hour of sexual intercourse. Erection of penis is supposed to start within 30 minutes after using the medication which is supposed to last for almost 4-5 hours depending upon the patient and external sexual stimulation.
Sildenafil acts by stopping the effect of a chemical called phosphodiesterase type-5 which is responsible for blood vessels relaxation of a penis and improving the flow of blood to the penis region in the presence of sexual stimulation. It affects the erectile tissue of penis enabling enhancement of the blood flow resulting in an erection of the penis. It is one of the safest drugs used for erectile dysfunction approved by FDA in 1997. There is no severe adverse effect reported after using Sildenafil which makes it very reliable to male patients having erectile dysfunction. The affordable price for this medication is appreciated by patients from different economic backgrounds.
Ajanta Pharma Information
Ajanta Pharmacy started its journey in the field of producing medicine in 1973. It’s an Indian company situated in Mumbai, Maharashtra. Now, this company has stepped more than thirty countries all over around the globe with their affordable price and appropriate quality. With the vision of ‘Serving Global Health Care Needs Worldwide’, a team of more than 6000 employees from Ajanta Pharma with different nationalities ensures providing best quality medicines to the patients in every corner of the world. In recent years, they have achieved 1st rank in India, for patient compliance and convenience. Their medications are already being sold in USA, Africa, Mauritius, India, Philippines and the Middle East. This company is well known for producing generic medicine at cheaper price and better quality compared to other companies. According to the information shared in the company’s official site, it has an approval from US FDA . People from all over the world praise Ajanta Pharma for tying up with World Health Organization in various charity programs to stop spreading of Malaria in Africa.
Currently, Ajanta Pharma operates 6 state-of-the-art manufacturing facilities; 5 within India and one in Mauritius. Quality is the primary focus of this company which is maintained by up to date sophisticated mechanisms of the company.
Clinical Study on Sildenafil
Sildenafil has been proven as a safe and effective medication for patients with erectile dysfunction by several scientific studies since last two decades. “Use of sildenafil in patients with cardiovascular disease”  is a research paper by author J Am Coll Cardiol which describes the effects of sildenafil on cardiac patients.
Male erectile dysfunction is outlined as “the inability to achieve erectile organ erection sufficient for satisfactory sexual performance”. It is one of the most common problems of men in the United States, affecting between 10 and 30 million. Sexual dysfunction in men after the diagnosis of coronary artery disease or a myocardial infarction is not unusual. Most are due to fear that the exertion of sexual activity will precipitate another myocardial infarction; however, 10% to 15% is because of organic reasons of impotence. Roughly 5.5 million men take nitrates on a daily basis for cardiopathy.
The introduction of sildenafil citrate (Viagra), a drug that works as an inhibitor of cGMP–unique phosphodiesterase kind 5 (PDE5), which leads to easy muscle relaxation, vasodilatation, and more desirable penile erection, has been a first-rate development within the treatment of erectile dysfunction. The vasodilating action of sildenafil affects each the arteries and the veins, so the most common facet outcomes of sildenafil are a headache and facial flushing. Sildenafil causes small decreases in diastolic and systolic blood pressures; however, clinically hypotension is rare. Research of sildenafil and nitrates taken together display a drop in blood pressure. Therefore, it’s contraindicated to use sildenafil in sufferers who take long-appearing nitrates or who use rapid-performing nitrate-containing medicinal medications.
Another research information named “The Past, Present, and Future of Sildenafil”  was published in International Journal of Practice by author Graham Jackson. It described that more than 750,000 physicians have prescribed sildenafil to more than 23 million men serving to establish a wonderful safety and affectivity record. Medical studies have verified that sildenafil effectively treats erectile dysfunction of irrespective of healthy, psychogenic or blended etiology, and is most effective in men with erectile dysfunction
There was a conflict about the duration of sildenafil activity which was solved by the author Clive Gingell who has completed a research work named “Duration of Action of Sildenafil Citrate in Men with Erectile Dysfunction”. He described that it usually works even after 4-5 hours after taking, in some extreme cases it was effective in a significant proportion of men with ED up to 12 hours after being taken .He described that it usually works even after 4-5 hours after taking, in some extreme cases it was effective in a significant proportion of men with erectile dysfunction up to 12 hours after being taken.
Mechanism of Action and Description of Sildenafil
The main mechanism behind the erection of the penis is preceded by sexual stimulation. NO, Nitric oxide is released then in the penile region and it activates guanylate cyclase causing the increase in levels of cGMP (cyclic guanosine monophosphate), which helps relax muscles in the corpus cavernosum in the penile area. This relaxation allows the inflow of blood take place. It is absorbed very fast and starts acting within 30 to 60 minutes after taking single dose; it has a plasma half-life time of roughly three hours.
Unlike other medication, it has no direct effect in penile erection rather it affects the response of external sexual stimulation. Sildenafil raises the effect of Nitric Oxide by inhibiting phosphodiesterase variety 5 (PDE5), the important reason behind the degeneration of cyclic guanosine monophosphate in the corpus cavernosum of the penis. It causes muscle relaxation and sufficient blood flow to the penis which results in the satisfactory erection of the penis.
Kamagra Oral Jelly Benefits
The Kamagra Oral jelly is expected to be absorbed faster than any other forms of Sildenafil. It starts working within one hour after the medication is taken. Patients get a satisfactory erection after 30 to 60 minutes after oral administration which last for 3 hours to 4 hours. It helps a good amount of blood flow in the Corpus Cavernosum of Penis. That’s why it not only helps the erectile dysfunction but also is beneficial to cure other problems in the penis. Patients are advised to take Kamagra Oral jelly after a light amount of food as it makes erection faster. The effect of Kamagra Oral jelly can vary from patient to patient.
Dosage and Recommended Therapy
Sildenafil can be advised in various doses like 25mg, 50mg, and 100mg. But, medical research showed that it works better as a primary dose in comparison to the other doses. It should be administered orally before 1hour of planned sexual intercourse. Physicians recommend the patient having erectile dysfunction not to use this medication more than one time a day.
Side effects and Warnings
Sildenafil doesn’t have any harmful effect in human body. It has very mild side effects which are caused by vasodilation caused by it. The common side effects caused by Kamagra Oral are as follows: epistaxis, flushing, loose motion, dyspepsia, vomiting, erythema, insomnia, dizziness, nausea and muscle ache .
Patients are to consider medical attention if any allergic reaction is found after using the medication
Oral administration of Sildenafil with nitric oxide donors like organic nitrates or organic nitrites in other form is contraindicated. Consistent with its known effects on the nitric oxide/cGMP pathway, sildenafil was found to potentiate the hypotensive effects Sildenafil augments low blood pressure effects of nitrates following its Nitric oxide/cGMP pathway.
It is advised to take precaution when alpha-blockers are interacted with Sildenafil because of potential additive blood pressure-lowering effects. When sildenafil is taken concurrently with alpha blocker drugs, users might be stable on this therapy. With an alpha-blocker, patients should be stable on alpha-blocker therapy. Sildenafil should be initiated at the lowest doses .
Customers are satisfied with the result they got from Viagra – Kamagra Jelly. Customers mentioned that this medication works unbelievably fast. Bryan who bought his supply at All Day Chemist (ADC) stated that “I am now a regular customer of ADC”.
Another customer told that the medication is great but it has very bad taste. One customer found Kamagra jelly is more useful than the pills. In the meantime, one customer among all experienced a few side effects caused by Kamagra Oral Jelly.
Price for Kamagra Oral Jelly, Available Forms, and Dosage
In the dealpharmarx.com, it is found that Kamagra Oral Jelly 60 pieces is available at 5$ per sachet. The total sum of products is 300$. Though they offer free shipping on qualified orders, the mentioned cost of standard shipping (19-20 days) and fast shipping (14-15 days) is respectively $22 and $25 to USA, Australia, Canada.
According to rxmedicaments.com, a price for 14 sachets of 100 mg Kamagra jelly is 57.50$, and they ask 14.95$ for shipping Kamagra Jelly to USA, Australia, Canada.
Conclusion and Rating
Kamagra Oral Jelly is an effective, safe and tolerable form of treatment for erectile dysfunction. Numerous trials conducted on the drug have proven its safety when used over a long term.
Kamagra Oral Jelly is a highly rated drug, with its effectiveness in the treatment and improvement of the sexual performance in patients dealing with erectile dysfunction. Patients, who follow the prescription of the drug well, experience less or no side effects at all and seem to enjoy the results since the erection and sexual activities are boosted. Patients of 18 years and below are disadvantaged since it is not advisable for them to use the drug due to the side effects. Patients of 65 years and above are not advised to overuse the drug due to the strict restriction.
I found so many reviews about the Kamagra Jelly 100mg. Customers are satisfied with the product. They feel that Kamagra jelly is better than other forms of Kamagra. They told that medicine acts very fast and they got an erection within 1 hour after taking it. Though one patient is not happy with this product, as he complained that Kamagra Jelly is so bad in taste. Some people may face mild side effects which are not so severe. I rate Kamagra Oral Jelly 4 out of 5.
Kamagra Oral Jelly Wiki Facts
- Brand: Kamagra Oral Jelly
- Active Ingredient: Sildenafil
- Treatment: Erectile Dysfunction
- Manufacturer: Ajanta
- Country of Manufacture: India
- Availability: USA, EU, New Zealand, UK, Australia, ++
- Cheitlin MD, Hutter AM, Brindis RG, Ganz P, Kaul S, Russell RO, Zusman RM, Forrester JS, Douglas PS, Faxon DP, Fisher JD. Use of sildenafil (Viagra) in patients with cardiovascular disease. Journal of the American College of Cardiology. 1999 Jan 1;33(1):273-82. Available from: http://circ.ahajournals.org/content/99/1/168
- Jackson G, Gillies H, Osterloh I. Past, present, and future: a 7‐year update of Viagra (sildenafil citrate). International journal of clinical practice. 2005 Jun 1;59(6):680-91. Available from: http://onlinelibrary.wiley.com/doi/10.1111/j.1368-5031.2005.00578.x/full
- Nichols DJ, Muirhead GJ, Harness JA. Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality. British journal of clinical pharmacology. 2002 Feb 1;53(s1):5S-12S. Available from: http://onlinelibrary.wiley.com/doi/10.1046/j.0306-5251.2001.00027.x/full
- Ajanta Pharma: Ajanta Pharma Overview, [cited 2016, 30th Nov]. Available from: http://www.ajantapharma.com/overview.html
- Gingell C, Sultana SR, Wulff MB, Gepi‐Attee S. Duration of action of sildenafil citrate in men with erectile dysfunction. The journal of sexual medicine. 2004 Sep 1;1(2):179-84. Available from: https://www.ncbi.nlm.nih.gov/pubmed/16422972
- MedicineNet: Sildenafil (erectile dysfunction) – oral, Viagra. [cited 2016 30th Nov 2016] Available from: http://www.medicinenet.com/sildenafil-oral/article.htm
- Elrod JW, Greer JJ, Lefer DJ. Sildenafil-mediated acute cardioprotection is independent of the NO/cGMP pathway. American Journal of Physiology-Heart and Circulatory Physiology. 2007 Jan 1;292(1):H342-7. Available from: https://www.ncbi.nlm.nih.gov/pubmed/16951048