One of the many forms of “Kamagra” products available in the market for Erectile Dysfunction treatment is the Effervescent Kamagra tablets. Kamagra products are made by Ajanta Pharma, which is a globally operating pharmaceutical company with its headquarters located in India.
This product also contains the active ingredient Sildenafil Citrate, which is the first line of treatment for Erectile Dysfunction since its approval on 1998 . Aside from being a treatment for ED, though, Sildenafil is also a known (but less common) treatment for pulmonary hypertension . Sildenafil identified action is to inhibit type 5 phosphodiesterases (PDE5) and since PDE5 is present in both the penile smooth muscle cells and in the pulmonary vasculature, it has effect in both the management of ED and in pulmonary hypertension . In Kamagra Effervescent case, however, Sildenafil is only indicated for treating ED and not pulmonary hypertension .
There is not much difference between Kamagra Effervescent tablets’ effectiveness and the effect of its Kamagra product counterparts, more so the ones containing the same amount of active ingredient. Kamagra Effervescent tablets contain 100 mg Sildenafil content  which is the standard active ingredient amount present in other Kamagra products. Some vendors of effervescent Kamagra tablets claim that the product works as fast as 20 minutes from intake  since its delivery does not require further enzyme breakdown like the hard pills.
Manufacturer Information (Ajanta Pharma Inc.)
The manufacturer, Ajanta Pharma is a pharmaceutical company which specializes in the manufacture, marketing, and development of high-quality, pharmaceutical-grade finished doses both in the local and global market . The company is well-known for giving its client an access to high-quality but less-costly generic medication which is at par with their famous brand-name analogs.
Ajanta currently holds one US FDA approval for 1 of its 5 state-of-the-art manufacturing facilities (the one in Aurangabad) and is preparing for the approval of another. According to the information on Profit.ndtv.com , its product portfolios are tailored to the needs of the countries it exports to. The main characteristic of Ajanta is its dedication to Research and Development of its products, as it has a separate advanced facility for the development of its API or Active Pharmaceutical Ingredients of different dosage forms plus finished formulations.
It is also notable that Ajanta Pharma has already entered the US market (2013) and it may be that the company aims to develop and grow its company’s operations in the US market. Currently, Ajanta Pharma is home to 6,000+ employees worldwide, with about 750 focused primarily on Research and development of current formulations and new products .
Studies on Sildenafil Citrate
In a study done by Sadovsky et.al. in 2001 entitled “Three-year update of sildenafil citrate (Viagra) efficacy and safety”, Sildenafil effect was evaluated three years since its launch. The study aimed to present how Sildenafil was able to affect its millions of patients worldwide . According to the study , the use of Sildenafil proved useful in treating ED as proven by the results of double-blind, placebo-controlled trials in ED patients, and also in patients with ED but with coinciding medical conditions like CVDs (cardiovascular diseases), diabetes, MS (multiple sclerosis), injuries on the spinal cord, and minor depression. Sildenafil also gave positive treatment outcomes in patients with terminal stage kidney failure, cancer of the prostate, spina bifida, Parkinson’s, and patients with multiple organ transplants . All in all, the result of the evaluation gave promising results for Sildenafil in ED, and also paved a way for the consideration of Sildenafil use in treatments for other diseases than ED . The only recorded side effects for Sildenafil use (in clinical trials), according to the study, were mild or moderate side effects which seldom lead to the termination of Sildenafil use by the patients .
Aside from being an effective agent for ED treatment, Sildenafil also proved to be well-tolerated by patients in either 50mg or 100mg form, according to the study “Safety of sildenafil citrate: review of 67 double-blind placebo-controlled trials and the post marketing safety database” by Guiliano et.al. in 2010 . The study confirmed that Sildenafil is generally safe to use by patients in both its 50 mg and 100 mg form. There is also no known overdose of Sildenafil in those amounts, and the research concluded that the use of Sildenafil in those registered doses are generally safe for patient use .
The usual perception for Sildenafil for ED treatment is usually limited to patients suffering only ED without underlying diseases, but there are studies showing that Sildenafil is not limited to treating patients with purely ED. One study, “A Placebo-Controlled, Multicenter, Randomized, Double-Blind, Flexible-Dose, Two-Way Crossover Study to Evaluate the Efficacy and Safety of Sildenafil in Men With Traumatic Spinal Cord Injury and Erectile Dysfunction” by Ergin et.al. (2008), determined Sildenafil’s effectiveness in treating spinal cord injury or SCI-related ED . SCI patients (complete and incomplete) responded well to the Sildenafil treatment as they showed significantly higher results in successful sexual stimulation/sexual life/sexual relationship, intercourse success, and improved Erectile Dysfunction Inventory of Treatment Satisfaction and with no relevant effects on the vital signs . However, Sildenafil treatment proved more effective in treating incomplete SCI patients than the complete SCI patients; but the effect of Sildenafil in complete SCI patients showed a significant difference over placebo .
However, although the effectiveness of Sildenafil for ED was established, there are some considerations which should be noted regarding its intake. “Groups advise on managing sildenafil’s cardiovascular risks” found on Am. J. Health-Syst. Pharm (1998) states that the use of Sildenafil in patients taking Nitrates for their coronary artery diseases, on antihypertensive medication, and patients on Erythromycin/Cimetidine is highly contraindicated, as per recommendation by the American College of Cardiology (ACC) and the American Heart Association (AHA) . Sildenafil is highly contraindicated for the patients taking the medications mentioned as the drug interaction proves to be potentially detrimental/hazardous in the least .
Sildenafil Citrate Course of Action
It is determined that Sildenafil acts as a selective and potent inhibitor of PDE5 (Phosphodiesterase type 5) found in both the pulmonary vasculature and the smooth muscle cells found in the penis . Since PDE5 is found in both locations, Sildenafil has the ability to modify the action of PDE5 in the penile muscle cells and in the pulmonary vasculature.
The inhibitory action of Sildenafil to PDE5 allows the presence of cyclic guanosine monophosphate (cGMP), which functions majorly the regulator of NO (nitric oxide), which is a vasodilator . In ED use, inhibition of PDE5 by Sildenafil causes the penile smooth muscle of the corpus cavernosum to relax, therefore mediating erections (only when stimulated) and aids in sustaining the erections . In patients with pulmonary hypertension, Sildenafil’s PDE5 inhibition leads to the decrease of the pulmonary artery pressure .
Sildenafil Citrate Effects on Patients
Sildenafil is a known treatment for patients suffering ED, whether it’s just ED or ED from a number of medical factors (for instance, spinal cord injuries) . The active ingredient action of mediating erection when needed is actually implied in patients suffering from ED, as there are many research backing the claim. But aside from the physiological benefit of Sildenafil, it is also found out to bring about improvements in the patients’ well-being, as determined by the study done by Tomlinson et.al. (2004) “Impact of erectile dysfunction and its subsequent treatment with sildenafil: qualitative study” . The study noted that patients who took Sildenafil for ED also exhibited improvements in their psychosocial well-being since ED associates with self-esteem problems, relationship problems, and distress. Apparently, treating ED in patients also helped them improve in the said areas .
As Kamagra Effervescent pills are made up of Sildenafil (100 mg), it is expected that the result will be the treatment of the dysfunction in those males affected by ED. The dose 100 mg is also considered the most effective Sildenafil dosing , so using Kamagra Effervescent tablets will lead to positive results in ED treatment (in patients eligible to be treated with the drug).
Recommended Doses and Duration of Therapy
The usual prescribed initial dose of Sildenafil in ED patients is either 50 mg or 100 mg, depending on their medical history, as the physician determines the dosage fit for the patient depending on his condition. Either one of the two mentioned doses are well-tolerated by patients with ED, although 100 mg seems to be more effective and more preferred by the patients . However, there is really no recommended extent of treatment for those patients taking Sildenafil for ED, since it is not really for drug maintenance, and its use, as indicated by Sildenafil manufacturer labels (and vendors), is only as-needed, and should not exceed 1 dose in a 24-hour period .
Side effects and Warnings
Side effects determined for Sildenafil due to its PDE5 inhibition are headaches, vasodilation, and facial flushing, and the results were more significant than the patients taking placebo . The data collated from the DBPC (double-blind placebo-controlled) trials with about 14,000 participants only showed side effects which included 11 occurrences of priapism, 0 cases of NAION (Non-Arteritic Anterior Ischemic Neuropathy), and only 1 case of unilateral (embolic) hearing loss .
There are also warnings for patients with several underlying medical conditions, and patients with other medical conditions are advised to consult with their physicians for the appropriate dosing and intake of any Sildenafil-containing product to avoid or lessen the occurrence of side effects .
Sildenafil has many known drug interactions so it is imperative that patients undergo full/complete medical assessment before taking any drug containing it, especially if patients have existing medical conditions prescription medications for them. Nitrates for CVD and other medical conditions are highly contraindicated, regardless of form (tablet, sublingual tablet, spray, ointment/paste, patch)  as they are known to lower the blood pressure  too, like Sildenafil medication. Aside from Nitrates, there are also a lot of other known drugs which may react with Sildenafil like blood thinners (warfarin-Coumadin), alpha-blockers, barbiturates, beta-blockers (metoprolol), erythromycin, seizure medication (carbamazepine), HIV protease inhibitors, and more .
Sildenafil products are always well-reviewed, but in the case of Kamagra Effervescent tablets, there were not so many available. But even if that was the case, the present reviews for the product were positive towards its effectiveness. For instance, the patient David Coventry in Pharmatheke-europe.com related how he just tried the effervescent Kamagra for “something new”, since he was always taking generic Sildenafil in pill form alone. According to him, the effervescent kind worked faster than the regular pills he previously took. He also noted that he experienced no side effects while taking the fizzy medication.
The review from Vince from Pharmacy2home.com was also indicative that he was pleased with the Kamagra’s effervescent variant. It is notable in his review that he was well-pleased with the product and even commented that the fizzy medication is the “best” Sildenafil product he had ever tried since it was able to give him the desired effect in less than an hour.
Although the reviews were scanty, it is enough to make the product recommendable. These users highly regarded Kamagra Effervescent Tablets due to its effectiveness and fast-acting nature, which both of the reviewers noted in their comments.
Price, Available Forms and Dosage
Kamagra Effervescent Tablets are generally affordable because they are generic by nature. Sellers sell the tablets affordable, for instance, Sureviagra.com, which sells the product for only at least $3.77 per unit. Sellers, however, give more discounts on purchases which have greater quantities.
Some internet pharmacies also give free shipping rates for buyers who can buy a certain order amount; for instance, Pharmstock.net. Shipping fees by suppliers technically vary depending on the preferred courier or delivery method of the buyers. Regular shipping is almost always cheaper and sometimes free, and the faster courier (EMS/Trackable) service is always more expensive (about $20 up), but generally faster. Shipping fees to the USA, Australia, and Canada are not destination-dependent and are almost always the same for all parts of the world.
Conclusion and Rating
Sildenafil had always been “the” treatment for Erectile Dysfunction and is widely used for ED with various etiologies. The treatment also was proven effective for conditions involving other diseases like SCI and helped to significantly improve the erectile response of the patients.
The active ingredient is already approved to treat ED and improve erectile response. But Sildenafil benefits don’t just stop there, as it is also commercially indicated for the treatment of Pulmonary Hypertension and has also been considered to cure other diseases.
Kamagra Effervescent tablets are also one of the products containing the most effective dose of Sildenafil (100 mg) for patients. The reviews toward the product have been positive, although the reviews were scanty compared to the other Kamagra products available on the market. User comments, however, relate how they found the product more preferable over the regular Sildenafil pills, as the effect of the effervescent tablets is observed faster by the users.
I think the effervescent version of Kamagra deserves 4 stars out of 5 due to its effectiveness and its quality since it was produced by a well-acclaimed company. I recommend its use for ED, as other users have recommended it too. It is also curious that the patients found the product to act faster than the regular pill form. Kamagra Effervescent is a good choice for ED treatment, especially for those wanting to try “something new” for their ED treatment.
Kamagra Effervescent Jelly Wiki Facts
- Brand: Kamagra Effervescent
- Active Ingredient: Sildenafil
- Treatment: Erectile Dysfunction
- Manufacturer: Ajanta
- Country of Manufacture: India
- Availability: Australia, UK, USA, EU, India, New Zealand, ++
- National Library of Medicine. Drug Record (Sildenafil). Available from: https://livertox.nlm.nih.gov/Sildenafil.htm [Accessed 29th November 2016].
- Kamagra Effervescent Tablets. Accessed from: http://www.amanentrp.net/kamagra-effervescent-tablets.htm [Accessed 29th November 2016].
- Kamagra Effervescent. Available from: http://www.sureviagra.com/kamagra-effervescent.html [Accessed 29th November 2016].
- Ajanta Pharma Ltd. Available from: http://profit.ndtv.com/stock/ajanta-pharma-ltd_ajantpharm/reports [Accessed 29th November 2016].
- Sadovsky R, Miller T, Moskowitz M, Hackett G. Three-year update of sildenafil citrate (Viagra) efficacy and safety. Int J Clin Pract. 2001, Mar; 55(2):115-28. Available from: https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~wDBsKt:2 [Accessed 29th November 2016].
- Giuliano F, Jackson G, Montorsi F, Martin-Morales A, Raillard P. Safety of sildenafil citrate: review of 67 double-blind placebo-controlled trials and the postmarketing safety database. Int J Clin Pract. 2010 Jan; 64(2): 240–255. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810448/ [Accessed 29th November 2016].
- Ergin S, Gunduz B, Ugurlu H, Sivrioglu K, Oncel S, Gok H, et.al. A Placebo-Controlled, Multicenter, Randomized, Double-Blind, Flexible-Dose, Two-Way Crossover Study to Evaluate the Efficacy and Safety of Sildenafil in Men With Traumatic Spinal Cord Injury and Erectile Dysfunction. J Spinal Cord Med. 2008; 31(5): 522–531. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2607124/ [Accessed 29th November 2016].
- Groups advise on managing sildenafil’s cardiovascular risks. Am. J. Health-Syst. Pharm.; VOL 55 ISS Oct 15 1998, P2080, 2083, (REF ). Available from: https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~gTVgQQ:1 [Accessed 29th November 2016].
- Tomlinson J, Wright D. Impact of erectile dysfunction and its subsequent treatment with sildenafil: qualitative study. BMJ. 2004 May 1; 328(7447): 1037. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC403839/ [Accessed 29th November 2016].
- U.S. National Library of Medicine. Sildenafil. Available from: https://medlineplus.gov/druginfo/meds/a699015.html